منابع مشابه
Genetic modification of somatic stem cells
Some of the illnesses that plague man kind are directly related to our genes. Severe genetic disorders with no current therapeutic options—immuno deficiencies, haemophilia, thalassaemia, muscular dystrophies and cystic fibrosis, for example—could potentially be treated with gene therapy, which uses genetic informa tion to correct a mutation or to provide new functions for human cells. the ai...
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Abbreviations: Ad: adenovirus, bFGF: basic fibroblast growth factor, BMP: bone morphogenetic protein, CNS: central nervous system, ES: embryonic stem, FACS: fluorescence activated cell sorting, HIV: human immunodeficiency virus, ICM: inner cell mass, LIF: leukemia inhibitory factor, MEF: mouse embryonic fibroblast, RNAi: RNA interference, SCNT: somatic cell nucleus transfer, UTR: untranslated r...
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Elucidating the critical epigenetics events involved in differentiation and reprogramming of cells to primordial germ cells (PGCs) is among the interesting issues in stem cell research. Here, I will talk about critical transcription factors and global hypomethylation in development of germ cells. Evidence strongly suggests that the earliest PGCs emerging in the E7.25 mouse embryo epiblast have...
متن کاملStem Cells Application in Modeling of Human Genetic Diseases
The use of animal models in modeling of human genetic disease has many advantages. In some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. Isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. They ar...
متن کاملEffect of Neurotrophin-3 on Differentiation of Rat Hair Follicle Stem Cells into Neural Like Cells
Purpose: The aim of this study was to evaluate the effect of NT-3 on the decrease of the differentiation time of bulge stem cells of rat hair follicle from neuron like cells.Materials and Methods: The bulge region of the rat whisker was isolated from and cultured in DMEM/F12 supplemented with epidermal growth factor (EGF) in 3 groups for 7, 8 and 9 days .Then 10 ng/ml NT-3 was added to each gro...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2008
ISSN: 1525-0016
DOI: 10.1038/sj.mt.6300402